Safflower (Carthamus tinctorius L.) is an internationally important oil crop. This experiment was carried out to evaluate the effects of Zinc foliar application rates (0, 200, 400 and 600ppm) on yield and yield components of safflower varieties (Gilla, G-2018, Rabeey500), a field experiment was conducted during growing season of 2023-2024 at Grdarasha experimental field research/Collage of Agricultural Engineering Science. A factorial experiment based on randomized complete block design (RCBD), with three replicates was used. Traits such as vegetative growth (plant height, leaf area, leaf area index, dry matter, crop growth rate), yield and yield components (No. of primary branches, no. of secondary branches, no. of head plant-1, no. of seed head-1, 1000 seed weight, seed yield, biological yield and Harvest index) and percentage of protein, protein yield, percentage of oil and oil yield in seeds. The highest rate of most of vegetative growth parameters were recorded by Gilla variety exception of plant height (148.34cm) and some of yield and yield components, like oil percentage (24.20%) and oil yield (4812.17kg ha-1) recoded by Rabeey500 variety, while G-2018 recorded the maximum level (7.20) of primary branches, (29.62%) of protein percentage and (5061.06kg ha-1) protein yield. Zn foliar application significantly increased all studied traits at 400ppm excepting of oil (23.48%) and protein percentage (29.11%) in seed were obtained with 600ppm Zn spray. Interaction between varieties and Zn spray also has significant differences for all characteristics measured, as well as, the maximum produce for these parameters were found with Gilla, Rabeey500 and 200, 400 and 600ppm of Zn spray.