The present study aimed to evaluate the effect of some dietary supplements (glutamine , creatine , whey protein and lipo6X) on the levels of blood proteins and some enzymes, and also included histopathological studys. Twenty albino rabbits were used in this study (6-7 months and 1500-1700 gm boody weight) and were divided into 5 groups (n=4): group 1 : control group received drinking tap water and ideal diet only, group 2: glutamine group (143mg kg body wt), group3: creatine group (250mg kg body wt), group 4: whey protein group (300mgkg body wt) and group 5: lipo6x (250mgkg body wt).
There was an increase in the level of total protein T.P and globuline in all treatments, while there was an increase in albumin level only in glutamine supplement. The results also showed an incease in the levels of enzyme; ALT , AST , LDH in all treatments.
This study also showed an increase in the weight of kidney and liver organs of studied rabbits in the glutamine and lipo6X groups, while there was weight decrease in the case of ceatine and whey protein compard to control group.
The supplemention also leads to some changes in the tissues of animals, which included many abnormalities in their liver and kidney. In kidney, the histological changes included; glomerulus hypertrophy, necrosis, damged capsule and infilterated lymphocytes, also congestion and hemolysis of RBC, which led to hematidin appearance as greenish granules. While in the liver, the tissue abnormalities included; cytoplasmic necrosis, karyolysis, blood congesion and infilterated lymphocyte. In addition kupffer cell hypertrophy and hepatic cell swelling observed in the liver tissue that led to colapse sinusoids and appearance congesion in the sinusoid.