This study was conducted in the poultry field - Animal Resources Department - College of Agriculture and Forestry - University of Mosul, for13 weeks (91days) from the 4th of December 2013 to the 3rd of March 2014. The objective of the study was to evaluate effects of partial replacement of nigella sativa meal instead of soybean meal in ration and its reflection on productive performance and some physiological characters of quails. Four hundred and thirty two , one day old unsexed quils were reared normally .the study divided to two stages .the 1st the period from seven day old until the age of sexual maturity (42) days .Birds randomly distributed into 4 treatments (9 replicates, 12 birds each). The experimental treatments were as follows :Treatment 1 control Treatments 2,3,4 were replacement 10,20,30 % of nigella sativa meal instead of soybean meal in ration respectively .Statistical analysis of data for the first stage showed that treatment 4 (replacement of 30% nigella sativa meal instead of soybean meal in ration) causes a significant decrease in live body weight , weight gain and in feed conversion ratio ,triglyceride , packed cell volume , mortality percentage . No significant effect in relative weight of edible organs ,dressing percentage , weight of carcass cuts and blood biochemical parameters (glucose , total protein , albumin) . Stage two (the period from 8 – 13 weeks) the results showed no significant differences in egg production percentage , egg weight ,feed conversion ratio , fertility and hatching percentage , egg quality characters .Significant increase in feed consumption ,yolk index , yolk weight for treatment 4 as compared with other treatments .