This study was conducted at the animal farm of the department of Animal Science, College of Agriculture, University of Tikrit, during the period from May 5, 2013 till January 15, 2014. The experiment included 48 ewes of Awassi breed with weight of 46.19±1.05 kg. Synchronization of estrus was done by vaginal sponges (Progestagen 20mg) for 12 days. The animals were divided into four groups. The animals were treated injected with hormones (GnRH 0.1mg, hCG 150IU and P4 12.5mg) intramuscular for the first, second, and third groups respectively, while the control one was injected with normal saline, eight doses, one per week, started from the first week of mating until the eighth week of pregnancy. The results showed that there was significant effect (P≤0.05) for treatments with GnRH, hCG, and P4 in the number of RBC (106/ml), the number of WBC (103/ml) during the early pregnancy is that the group of P4 had high concentration in Hb (gm/100ml) and the group hCG in the PCV % during early pregnancy stages. Furthermore, the control group significantly (P≤0.05) increased in the levels of Albumin and Globulin. However, the groups of GnRH and hCG increased in the level of Cholesterol.