This experiment was carried out at two different locations, the first location (Duhok) and the second location Zakho (Batifa) during spring growing season (2023). To determine the effect of three concentrations of nano fertilizers (0, 5 and 9 gL-1) and three concentrations of licorice root extract (0, 8 and 16 g L-1) on two cultivars of pumpkin (A cv. and B cv.). The results appeared that the B cv. was superior over the A cv. in weight of fruit (kg), phosphorus%, fruit number, nitrogen potassium%, and calcium% under both locations, nitrogen% in the first location. Foliar application of 5 g L-1 nano fertilizer. significantly increased all the studied vegetative growth, yield and nutrient contents in both locations. Foliar application of 16g L-1 licorice root extract gave the highest significant value of plant height (cm), number of fruit.plant, nitrogen%, potassium% and calcium% under both locations, while 5 g L-1 significantly increased weight of fruit (kg) .The combined influences of two factors, namely cultivars and nano fertelizer., cultivars and licorice root extract and nano fdert, and licorice root extract, significantly enhanced most of the studied parameters. The triple interaction among three factors caused positive significant differences in all vegetative growth, weight of fruit kg. fruit and nutrient content in both locations. namely cultivars and nano fertelizer., cultivars and licorice root extract and nano fdert, and licorice root extract, significantly enhanced most of the studied parameters. The triple interaction among three factors caused positive significant differences in all vegetative growth, weight of fruit kg. fruit and nutrient content in both locations.